Plain-English translation of NCT05486884 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
After someone survives out-of-hospital cardiac arrest, their brain can be damaged from lack of oxygen. This trial tests whether norepinephrine—a medication that raises blood pressure—should be used to maintain a higher blood pressure target (90 mmHg) versus the standard target (65 mmHg) in the first 24 hours after the heart restarts. Researchers believe a higher blood pressure might help the brain get better blood flow and improve how well people recover.
Most people who survive cardiac arrest suffer serious brain damage because their brains don't get enough blood flow during recovery. Doctors currently aim for a minimum blood pressure, but no one knows if keeping blood pressure higher in those critical first hours could protect the brain better and help patients recover more of their mental abilities.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you will be randomly assigned to one of two groups. One group will receive norepinephrine to maintain a higher blood pressure (90 mmHg) for the first 24 hours, while the other group will receive the medication to maintain a standard blood pressure (65 mmHg). After 24 hours, both groups will be treated the same way. Medical staff will monitor your blood pressure closely and adjust the medication as needed. The trial continues while you are in the intensive care unit.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
France