Early detection of heart disease in carriers of a genetic mutation

This study is looking for very early signs of a hereditary heart condition called transthyretin cardiac amyloidosis (or ATTR) in people who carry a specific genetic mutation (V122I). Researchers will use advanced heart imaging and special blood tests to find disease before it causes symptoms, when newer treatments might be most effective.

This genetic mutation is common in Black Americans and can lead to serious heart problems and early death, but many people don't know they carry it. The condition is often found too late for the best treatment options. This study aims to catch it early, when new stabilizing medications may work better to prevent heart failure.