Plain-English translation of NCT05491512 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether people with HPV-positive throat cancer can be treated successfully with lower doses of radiation therapy while still receiving standard chemotherapy. The study uses chemotherapy drugs like , , paclitaxel, and (5-FU), which are already approved treatments. Researchers hope that reducing the radiation dose while keeping the chemotherapy may help shrink tumors while causing fewer side effects.
Standard treatment for HPV-positive throat cancer uses radiation and chemotherapy together, but both can cause significant side effects that affect quality of life. This trial is exploring whether the medication can work just as well with a lower radiation dose, potentially making treatment easier for patients to tolerate.
You likely qualify if…
You likely don't qualify if…
You would receive radiation therapy at a lower dose than standard, given over several weeks while also receiving chemotherapy infusions on a schedule determined by your doctor. Depending on which group you are assigned to, you may receive one cycle of chemotherapy starting the same week as radiation, or induction chemotherapy before radiation begins. You will have imaging scans and blood tests throughout treatment to monitor how well the therapy is working and track any side effects.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States