Plain-English translation of NCT05491655 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new way to use an implanted heart device called His bundle pacing in people with heart failure who have a normal QRS duration (a measurement on a heart rhythm test). His bundle pacing is a technique that sends electrical signals directly to a specific part of your heart's electrical system to help it beat more effectively. The goal is to see if this approach can improve heart function and reduce symptoms in people whose standard treatments haven't fully worked.
Most current pacing therapies work best for people with a specific type of heart electrical problem (wide QRS), but they don't help people with normal QRS patterns. This trial exists to see if this new pacing technique might help this group of patients who currently have limited options.
You likely qualify if…
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You will have a device implanted with a special lead positioned in your heart's electrical system. For the first month, your device will be tested and adjusted to find the right settings. Then you'll be randomly assigned to one of two groups: one group will receive continuous His bundle pacing therapy for six months, while the other group will use the device only as a backup. You'll have follow-up visits to monitor how you're doing and measure how well your heart is working.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
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