A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer — Stella
Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.
(110 sites) United States
University of California at San Diego, La Jolla, California University of California Irvine, Orange, California Stanford Cancer Institute, Stanford, California Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital, Washington D.C., District of Columbia Baptist Lynn Cancer Institute, Boca Raton, Florida Mount Sinai Medical Center, Miami Beach, Florida AdventHealth, Orlando, Florida H. Lee Moffitt Cancer & Research Institute, Tampa, Florida University of Kansas Cancer Center, Westwood, Kansas Sidney Kimmel Cancer Center - Bayview Campus, Baltimore, Maryland Boston Medical Center, Boston, Massachusetts Washington University School Of Medicine, St Louis, Missouri Hackensack University Medical Center, Hackensack, New Jersey Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey Hematology-Oncology Associates of CNY, East Syracuse, New York Novant Health 1, Charlotte, North Carolina Novant Health, Winston-Salem, North Carolina Cleveland Clinic 1, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic 2, Mayfield Heights, Ohio Cleveland Clinic 3, Warrensville Heights, Ohio The Huntsman Cancer Institute, Salt Lake City, Utah Virginia Cancer Specialists, Fairfax, Virginia Providence Regional Cancer Partnership, Everett, Washington Virginia Mason Medical Center, Seattle, Washington Swedish Cancer Institute, Seattle, Washington Brazil
Fundacao Pio XII, Barretos PERSONAL Oncologia de Precisao e Personalizada, Belo Horizonte Instituto do Cancer de Londrina Hospital do Cancer de Londrina, Londrina Associacao Hospitalar Moinhos de Vento, Porto Alegre Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro Instituto D Or de Pesquisa e Ensino IDOR 1, Salvador Hospital Alemao Oswaldo Cruz, São Paulo Impar Servicos Hospitalares SA Hospital Nove de Julho, São Paulo Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo China
Affiliated Hospital of Hebei University, Baoding Jilin cancer hospital, Changchun Sichuan Cancer Hospital, Chengdu West China Hospital Sichuan University, Chengdu The First Affiliated Hospital of PLA Army Medical University, Chongqing The First Affiliated Hospital Sun Yat sen University, Guangzhou The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou Harbin medical university cancer hospital, Harbin Huizhou Municipal Central Hospital, Huizhou Liuzhou people's Hospital, Liuchow Fudan University Shanghai Cancer Center, Shanghai Tianjin Medical University General Hospital, Tianjin
France
Centre Francois Baclesse, Caen Centre Georges-François Leclerc, Dijon Institut de Cancérologie du Gard, Nîmes Institut de cancerologie de l'ouest, Saint-Herblain Gustave Roussy, Villejuif Germany
Evangelische Lungenklinik Berlin, Berlin Universitaetsklinikum Koelnt, Cologne LungenClinic Grosshansdorf GmbH, Grosshandorf Lungenfachklinik Immenhausen, Immenhausen Klinikum Würzburg Mitte gGmbH Standort Missioklinik, Würzburg Israel
Rambam Medical Center, Haifa Shaare Zedek Medical Center, Jerusalem Meir Medical Center, Kfar Saba Rabin Medical Center, Petah Tikva Sheba Medical Center, Ramat Gan Italy
Policlinico Hospital San Martino- IRCCS for Oncology, Genova Ospedale San Raffaele, Milan ASST Grande Ospedale Metropolitano Niguarda, Milan Azienda Ospedaliera San Gerardo, Monza Azienda Ospedaliera Specialistica dei Colli, Naples Japan
National Hospital Organization Himeji Medical Center, Himeji Saiseikai Matsusaka Municipal Hospital, Matsusaka Niigata Cancer Center Hospital, Niigata Shizuoka Cancer Center, Shizuoka The Cancer Institute Hospital of JFCR, Tokyo Wakayama Medical University Hospital, Wakayama Malaysia
University Malaya Medical Centre, Kuala Lumpur Hospital Tengku Ampuan Afzan, Kuantan Hospital Umum Sarawak, Kuching Beacon Hospital Sdn Bhd, Petaling Jaya South Korea
National Cancer Center, Goyang-si Seoul National University Bundang Hospital, Seongnam-si Seoul National University Hospital, Seoul Severance Hospital Yonsei University Health System, Seoul Asan Medical Center, Seoul Spain
Hosp Univ A Coruna, A Coruña General University Hospital of Alicantet, Alicante Hosp. de La Santa Creu I Sant Pau, Barcelona Hosp Univ Vall D Hebron, Barcelona Inst. Cat. Doncologia-H Duran I Reynals, Barcelona Hosp. Gral. Univ. Gregorio Maranon, Madrid Hosp. Univ. Ramon Y Cajal, Madrid Hosp. Univ. 12 de Octubre, Madrid Hosp. Univ. La Paz, Madrid Hosp Regional Univ de Malaga, Málaga Hosp. Virgen Macarena, Seville Hosp. Clinico Univ. de Valencia, Valencia Hosp. Gral. Univ. Valencia, Valencia United Kingdom
Cheltenham General Hospital, Cheltenham Torbay Hospital-Devon, Devon Edinburgh Cancer Centre Western General, Edinburgh Leicester Royal Infirmary, Leicester University College London Hospitals, London Nottingham City Hospital, Nottingham Queen Alexandra Hospital, Portsmouth
Key details Sponsor
Janssen Research & Development, LLC
Enrollment target
~520 participants
Primary completion
August 2027
Age range
18 Years and older
Last updated April 2026
Interested in joining? The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan Hospital of Jiangnan University, Wuxi The First Affiliated Hospital of Xian Jiaotong University, Xi'an Yantai Yuhuangding Hospital, Yantai