Plain-English translation of NCT05498428 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Carcinoma, Non-small-Cell Lung research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing , a new medication given as an injection under the skin, for people with advanced lung cancer that cannot be treated with surgery or radiation. The study combines this medication with other treatments that have already been approved, to see if this combination works better and is safe. Different groups of patients will receive different combinations depending on their specific cancer type and treatment history.
Some patients with advanced lung cancer have specific genetic mutations in their tumors that make them resistant to current treatments, or they may stop responding to existing medications over time. This trial is testing whether this new treatment approach can help patients whose cancer has these mutations or who have become resistant to other therapies.
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Participants will visit the clinic regularly to receive injections of the medication under the skin, along with oral tablets or chemotherapy depending on which group they are in. Treatment cycles typically last 28 days, with injections given on specific days during each cycle. You will have blood tests and imaging scans to monitor how your cancer is responding and to check for any side effects. The study is ongoing, so the exact duration depends on how well the treatment works and whether you experience side effects that require stopping the medication.
AI-generated summary from trial data · Jul 14, 2026 · Not medical advice
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