Plain-English translation of NCT05498675 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how a medication called sacubitril/valsartan affects the heart in people with high blood pressure. The study will compare this medication to other commonly prescribed blood pressure drugs and use special heart imaging (called cardiac MRI) to see which one works best at protecting heart health. The researchers are also looking at whether a person's weight affects how well the medication works.
High blood pressure and weight gain both put stress on the heart over time. While this medication is known to help people with heart failure, doctors aren't sure whether it works equally well for all body types, or whether it's better than other blood pressure medications for preventing heart problems in everyday patients.
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If you join, you will either continue taking sacubitril/valsartan (if you're already on it) or be in a comparison group taking other standard blood pressure medications. Researchers will use a special MRI machine to take detailed pictures of your heart to see how it's functioning. The study will follow you over time to track whether the medication is helping protect your heart health.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
China
Sponsor
Beijing Friendship Hospital
Enrollment target
~180 participants
Started
September 2021
Primary completion
December 2026
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in February 2025.
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Central contact
Rongchong Huang, M.D.
Beijing Friendship Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.