Plain-English translation of NCT05499702 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This research study is testing how calorie restriction—eating about 900 calories per day for 6 weeks—affects the way your body controls blood sugar and processes nutrients. Researchers want to understand whether eating fewer calories helps your liver work better with a hormone called glucagon, which plays an important role in managing blood sugar.
Many people with type 2 diabetes have trouble controlling blood sugar after eating, and their bodies don't properly respond to glucagon. This study is trying to figure out whether eating fewer calories can fix this problem by helping the liver become more sensitive to the hormone—and whether reducing fat in the liver is part of what makes this work.
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You will be asked to follow a strict 900-calorie daily diet for 6 weeks, with weekly meetings with a dietician to check in on how you're doing and review your food intake. After the 6 weeks, you'll come to the research center for a metabolic test where doctors will infuse a hormone called glucagon while monitoring how your body responds, to see whether the diet improved how your liver handles blood sugar and nutrients.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States