Testing two drug combinations to shrink advanced lung cancer before surgery

Plain-English translation of NCT05503667 on ClinicalTrials.gov ↗ · Source last updated August 2022 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This study is testing whether , a targeted lung cancer medication, works better when combined with another drug called , or when used alone. The goal is to shrink tumors before surgery so doctors can remove them more completely. This treatment is only for patients whose lung cancer has a specific genetic mutation (EGFR) that makes their cancer respond well to this type of medication.

For advanced lung cancer patients, surgery offers the best chance of long-term survival, but tumors are often too large to remove safely. Researchers want to know if giving this medication before surgery can shrink tumors enough to make surgery possible, and whether combining it with a second drug might work even better.

Do you qualify?

You likely qualify if…

you have been diagnosed with stage III or IV lung adenocarcinoma with an EGFR gene mutation
your cancer has not spread to multiple organs (no widespread metastasis)
your doctor believes you could potentially have surgery to remove your lung tumor
you have good lung function and overall health to tolerate both medication and surgery
you are at least 18 years old and able to sign a consent form

You likely don't qualify if…

you have already received chemotherapy, targeted therapy, or other cancer treatment for lung cancer
you have serious heart disease, uncontrolled high blood pressure, or other unstable medical conditions
you are pregnant, breastfeeding, or unable to use reliable contraception during and after the trial
you have an active infection or untreated HIV
you are allergic to either of the medications being tested

What participation looks like

You would be randomly assigned to receive either the medication alone or combined with a second drug, taken by mouth before surgery. You would have regular clinic visits for blood tests, scans, and check-ups to monitor how well the treatment is working. After several weeks of treatment, you would have surgery to remove the tumor, followed by additional follow-up care and monitoring to track your recovery and long-term outcomes.

AI-generated summary from trial data · Jun 30, 2026 · Not medical advice

Trial locations(1 site)

China

Shanghai Pulmonary Hospital, Shanghai, Shanghai Municipality