Plain-English translation of NCT05507099 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing two different sources of stem cells—one taken from fat tissue and one from bone marrow—to see which works better for relieving arthritis pain in the knee and hip. You would receive a single injection of one type directly into your affected joint. Researchers want to understand how much pain relief each treatment provides and how long that relief lasts.
Many people with osteoarthritis don't get enough relief from standard treatments like physical therapy, medication, or steroid injections. This trial explores whether stem cell therapy—which may help reduce inflammation and repair damaged tissue—could be a better option for people with moderate to severe joint pain.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive one type of stem cell injection into your knee or hip. The injection is a single procedure performed at the study site. You'll then be monitored over time through follow-up visits and phone calls to track your pain levels, how well your joint functions, and how much pain medication you need. The study will assess how long your pain relief lasts and watch for any side effects.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Canada
Phase
Testing effectiveness
Sponsor
Grigory Karmy
Enrollment target
~400 participants
Started
August 2022
Primary completion
August 2028
Age range
18 Years – 95 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Grigory Karmy, MD
McMaster University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.