Plain-English translation of NCT05507138 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a digital treatment called AKL-T01—an iPad-based program that combines videogame-like cognitive exercises with one-on-one coaching from a clinician. The study is designed for people who have had a stroke and are now struggling with depression and executive dysfunction (difficulty with planning, decision-making, and mental flexibility). Researchers want to see if this combination approach can improve mood, thinking skills, and daily functioning better than general cognitive games alone.
After a stroke, many people develop depression along with problems concentrating and planning—and existing treatments don't always work well or are hard to access. This trial explores whether combining cognitive training with personalized coaching delivered remotely might be a more effective and accessible option for stroke survivors.
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If you join this study, you will be randomly assigned to one of two groups. You will use an iPad for about 25 minutes per day, 5 days a week, for 6 weeks—either playing the cognitive training game (AKL-T01) or general brain-stimulation games. In addition, you will attend a weekly 45-minute virtual coaching session with a clinician who will help you reflect on what you're learning and apply it to your daily life. You will also complete thinking and mood assessments before, during, and after the study, and some participants will have an MRI brain scan to see if the treatment changes brain activity.
AI-generated summary from trial data · Aug 29, 2026 · Not medical advice
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