Plain-English translation of NCT05515354 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing whether the timing of your quit date matters for smoking cessation. Researchers want to know if scheduling your quit attempt during a specific phase of your menstrual cycle—either early in your cycle or just before your period—combined with nicotine replacement therapy (nicotine patches plus gum or lozenges) and behavioral support, helps you successfully quit smoking and stay smoke-free. The study will track your success at 7 days, at the end of treatment, and 6 months after your quit date.
Research suggests that hormonal changes during your menstrual cycle may affect how easily you can quit smoking, but past studies have been too small to know for sure. This larger, carefully designed study aims to clarify whether timing your quit attempt to a particular cycle phase really does improve your chances of success.
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You will join an online smoking cessation program lasting about 6 weeks. After providing information about your menstrual cycle, you will be randomly assigned to one of three groups: one group will pick a quit date during the first half of their cycle, another during the second half, and the third group will choose any date within 30 days. Everyone receives a 6-week supply of nicotine patches and your choice of nicotine gum or lozenges to start on your quit date. You will also get access to a free app, educational videos, and behavioral support to help you cope with cravings and stick to your quit plan. The study will check in with you at 7 days, at the end of treatment, and again 6 months after you quit.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
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