Plain-English translation of NCT05516719 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is looking for a biological marker—a measurable sign in the brain—that could help doctors understand how Parkinson's disease progresses over time. Researchers will use advanced brain imaging scans (PET and MRI) along with blood and spinal fluid tests to track changes in people with Parkinson's disease, people at genetic risk, and healthy volunteers over two years. The goal is to find better ways to detect disease progression early, which could eventually help develop new treatments to slow down symptoms.
Parkinson's disease causes movement problems, stiffness, and shaking that get worse over time, but doctors don't have a reliable way to predict how quickly someone's symptoms will worsen. By identifying a clear biological marker of disease progression, researchers hope to enable faster development of new medications designed to slow or delay Parkinson's symptoms.
You likely qualify if…
You likely don't qualify if…
You would visit the research center in London four times over two years (two visits per year, spaced 12 months apart). At each visit, you would have brain imaging scans (MRI and PET), clinical assessments, memory and thinking tests, and blood/urine samples taken. You would also have the option to provide a spinal fluid sample through a lumbar puncture procedure. The scans use a special tracer that highlights certain cells in the brain to help researchers see how the disease is changing.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United Kingdom
Sponsor
University of Exeter
Enrollment target
~44 participants
Started
November 2021
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
25 Years and older
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Marios Politis, Professor
University of Exeter
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.