A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(266 sites) United States
Cancer and Blood Specialty Clinic, Los Alamitos, California Sharp Memorial Hospital, San Diego, California Local Institution - 0273, West Hollywood, California Local Institution - 0381, Aurora, Colorado UConn Health, Farmington, Connecticut Local Institution - 0208, New Haven, Connecticut Advanced Research, Coral Springs, Florida Florida Cancer Specialists - South, Fort Myers, Florida Florida Cancer Specialists - North, St. Petersburg, Florida Florida Cancer Specialists - East, West Palm Beach, Florida University Cancer Blood Ctr, Athens, Georgia Local Institution - 0048, Marietta, Georgia Local Institution - 0330, Garden City, Kansas University of Kansas Medical Center, Westwood, Kansas Argentina
Local Institution - 0318, Chivilcoy, Buenos Aires Local Institution - 0213, Buenos Aires, Buenos Aires F.D. Local Institution - 0249, Córdoba, Córdoba Province Local Institution - 0239, Viedma, R Local Institution - 0200, Rosario, Santa Fe Province Local Institution - 0248, S3000epv, Santa Fe Province Local Institution - 0214, Buenos Aires Australia
Local Institution - 0055, Liverpool, New South Wales Local Institution - 0004, Waratah, New South Wales Local Institution - 0017, Wollongong, New South Wales Local Institution - 0327, Birtinya, Queensland Local Institution - 0221, Box Hill, Victoria Local Institution - 0003, Melbourne, Victoria Local Institution - 0002, Melbourne, Victoria Local Institution - 0040, Nedlands, Western Australia Austria
Klinik Ottakring, Vienna, State of Vienna Universitätsklinikum Krems, Krems LKH Hochsteiermark - Standort Leoben, Leoben Universitätsklinikum St. Pölten, Sankt Pölten Hanusch-Krankenhaus, Vienna Belgium
Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk, Limburg UZ Gent, Ghent, Oost-Vlaanderen AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, Salvador, Estado de Bahia Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, Rio Grande do Sul Instituto Joinvilense de Hematologia e Oncologia, Joinville, Santa Catarina Hospital Amaral Carvalho, Jaú, São Paulo Americas Centro de Oncologia Integrado, Rio de Janeiro Clínica Médica São Germano S/S Ltda, São Paulo Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo Canada
Local Institution - 0225, Greenfield Park, Quebec Local Institution - 0174, Montreal, Quebec Local Institution - 0222, Québec, Quebec Chile
Local Institution - 0329, Santiago, Santiago Metropolitan Local Institution - 0387, Santiago, Santiago Metropolitan Local Institution - 0332, Viña del Mar, Valparaiso China
Local Institution - 0062, Beijing, Beijing Municipality Local Institution - 0165, Beijing, Beijing Municipality Local Institution - 0141, Beijing, Beijing Municipality Local Institution - 0144, Chongqing, Chongqing Municipality Local Institution - 0237, Xiamen, Fujian Local Institution - 0117, Guangzhou, Guangdong Local Institution - 0177, Guangzhou, Guangdong Local Institution - 0168, Guangzhou, Guangdong Local Institution - 0238, Shenzhen, Guangdong Local Institution - 0412, Liuchow, Guangxi Local Institution - 0240, Nanning, Guangxi Local Institution - 0254, Shijiazhuang, Hebei Local Institution - 0395, Luoyang, Henan
Czechia
Fakultní nemocnice Brno Bohunice, Brno, Brno-město Fakultni nemocnice Kralovske Vinohrady, Prague, Praha 10 Vseobecna fakultni nemocnice v Praze, Prague Finland
Kuopion Yliopistollinen Sairaala, Kuopio, Northern Savonia Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki France
Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, Alsace CHU Bordeaux Haut-Leveque, Pessac, Aquitaine Centre Leon Berard, Lyon Cedex08, Auvergne-Rhône-Alpes Hopital Claude Huriez - CHU de Lille, Lille, Nord Centre Hospitalier Universitaire Estaing, Clermont-Ferrand Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau, Nîmes Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours Hôpital Saint Antoine, Paris, Île-de-France Region Germany
TUM Klinikum, München, Bavaria Klinikum Traunstein, Traunstein, Bavaria Medizinisches Versorgungszentrum, Weiden, Bavaria Universitätsklinikum Marburg, Marburg, Hesse Praxis Onkologie am Raschplatz, Hanover, Lower Saxony Universitätsklinikum Bonn, Bonn, North Rhine-Westphalia Marien Hospital Düsseldorf, Düsseldorf, North Rhine-Westphalia Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein Local Institution - 0396, Erfurt, Thuringia Universitätsklinikum Aachen, Aachen Sozialstiftung Bamberg, Bamberg Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden Universitaetsklinikum Hamburg-Eppendorf, Hamburg
Greece
Evangelismos General Hospital of Athens, Athens, Attikí Alexandra General Hospital of Athens, Athens, Attikí G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki India
HCG Aastha Cancer Centre, Ahmedabad, Gujarat Marengo Asia Hospitals Gurugram, Gurugram, Haryana KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi, Karnataka Mumbai Oncocare Centre - Nanachowk, Mumbai, Maharashtra Meenakshi Mission Hospital and Research Centre, Madurai, Tamil Nadu Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh Christian Medical College & Hospital, Ludhiana Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry Ireland
University College Hospital - Galway, Galway, Connacht Cork University Hospital, Cork St. James's Hospital, Dublin Local Institution - 0251, Limerick Israel
Meir Medical Center, Kfar Saba, Central District Sheba Medical Center, Ramat Gan, Central District Hadassah Medical Center - Do Not Use - Duplicate Facility, Jerusalem, Jerusalem Rambam Health Care Campus, Haifa, Northern District Sourasky Medical Center, Tel Aviv, Tall Abīb Rabin Medical Center, Peatch Tikva Italy
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna Azienda Ospedaliera Sant'Andrea, Rome, Roma Policlinico "G. Rodolico", Catania, Sicily IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna Fondazione IRCCS Policlinico San Matteo, Pavia Japan
National Cancer Center Hospital East, Kashiwa, Chiba Japan Community Healthcare Organization Kyushu Hospital, Kitakyushu-shi, Fukuoka National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido Mito Medical Center, Higashiibaraki, Ibaraki Iwate Medical University Hospital, Shiwa-gun Yahaba-cho, Iwate Shonan Kamakura General Hospital, Kamakura, Kanagawa Saitama Medical University Hospital, Iruma, Saitama Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Shizuoka Nihon University Itabashi Hospital, Itabashiku, Tokyo Chiba University Hospital, Chiba National Hospital Organization Kyushu Medical Center, Fukuoka Japanese Red Cross Fukuoka Hospital, Fukuoka New Zealand
Local Institution - 0335, Tauranga, Bay of Plenty Local Institution - 0340, Dunedin, Otago Local Institution - 0369, Auckland Local Institution - 0334, Auckland Poland
Local Institution - 0346, Skórzewo, Greater Poland Voivodeship Local Institution - 0224, Torun, Kuyavian-Pomeranian Voivodeship Local Institution - 0325, Krakow, Lesser Poland Voivodeship Local Institution - 0250, Warsaw, Masovian Voivodeship Local Institution - 0292, Słupsk, Pomeranian Voivodeship Pratia Onkologia Katowice, Katowice Portugal
Champalimaud Foundation, Lisbon Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto Puerto Rico
Local Institution - 0355, San Juan Romania
Fundeni Clinical Institute, Bucharest Institutul Oncologic Cluj, Cluj-Napoca Institutul Regional de Oncologie Iasi, Iași South Africa
Netcare Pretoria East Hospital, Centurion, GP Groote Schuur Hospital, Cape Town, Western Cape Haemalife, Kuilsriver, Western Cape Constantiaberg Haematology, Plumstead, Western Cape South Korea
Local Institution - 0106, Busan, Busan Pusan National University Hospital, Busan, Busan Local Institution - 0102, Seongnam, Gyeonggido Seoul National University Bundang Hospital, Seongnam, Gyeonggido Chonnam National University Hwasun Hospital, Hwasun, Jeonranamdo Local Institution - 0103, Hwasun, Jeonranamdo Local Institution - 0101, Seoul, Seoul Teugbyeolsi Seoul National University Hospital, Seoul, Seoul Teugbyeolsi Samsung Medical Center, Seoul, Seoul Teugbyeolsi Local Institution - 0104, Seoul, Seoul Teugbyeolsi The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul Teugbyeolsi Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul] Local Institution - 0105, Seoul, Seoul-teukbyeolsi Spain
Local Institution - 0183, Palma, Balearic Islands Hospital Universitari Son Espases, Palma, Balears [Baleares] Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña] Local Institution - 0073, Barcelona, Catalunya [Cataluña] Hospital General Universitario Morales Meseguer, Murcia, Murcia, Región de Hospital Costa del Sol, Marbella, Málaga Local Institution - 0182, Marbella, Málaga Hospital San Pedro de Alcantara, Cáceres Complejo Asistencial Universitario de León - Hospital de León, León Hospital Universitario 12 de Octubre, Madrid Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals, Ankara Liv Hospital Ankara, Ankara Istanbul University, Istanbul Faculty of Medicine, Istanbul Ege Universitesi Hastanesi, Izmir Erciyes Universitesi Tıp Fakultesi Hastaneleri, Kayseri Ondokuz Mayıs Universitesi, Samsun United Kingdom
Addenbrooke's Hospital, Cambridge, Cambridgeshire The Royal Cornwall Hospital, Truro, England Lanarkshire NHS Trust - Monklands Hospital, Airdrie, Great Britain King's College Hospital, London, Greater London Leicester Royal Infirmary, Leicester, Leicestershire Hammersmith Hospital, London, London, City of Freeman Hospital, Newcastle upon Tyne Royal Stoke University Hospital, Stoke-on-Trent
Key details Enrollment target
~810 participants
Primary completion
January 2027
Age range
18 Years and older
Last updated March 2026
Interested in joining? Our Lady of the Lake RMC, Baton Rouge, Louisiana Local Institution - 0255, New Orleans, Louisiana Local Institution - 0385, Shreveport, Louisiana Sinai Hospital Of Baltimore, Baltimore, Maryland Dana-Farber Cancer Institute, Boston, Massachusetts University of Michigan, Ann Arbor, Michigan Henry Ford Hospital, Detroit, Michigan Minnesota Oncology Hematology, P.A., Minneapolis, Minnesota Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi Local Institution - 0242, Jackson, Mississippi Astera Cancer Care, East Brunswick, New Jersey Local Institution - 0363, Ridgewood, New Jersey University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico Local Institution - 0245, Buffalo, New York Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York Local Institution - 0373, New Hyde Park, New York Local Institution - 0371, New York, New York Rochester General Hospital, Rochester, New York New York Cancer and Blood Specialists, Shirley, New York Local Institution - 0372, The Bronx, New York Local Institution - 0274, Williamsville, New York Duke Cancer Institute, Durham, North Carolina Oncology Hematology Care, Cincinnati, Ohio Fairview Hospital, Cleveland, Ohio Cleveland Clinic, Cleveland, Ohio Cleveland Clinic - Hillcrest Hospital, Mayfield Heights, Ohio Lehigh Valley Health Network, Allentown, Pennsylvania Local Institution - 0264, York, Pennsylvania The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee Texas Oncology - West Texas, Abilene, Texas University of Texas MD Anderson Cancer Center, Houston, Texas Mays Cancer Center, San Antonio, Texas Texas Oncology - San Antonio, San Antonio, Texas Utah Cancer Specialists, Salt Lake City, Utah Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia Virginia Oncology Associates, Norfolk, Virginia Blue Ridge Cancer Care, Roanoke, Virginia VA Puget Sound Health Care System, Seattle, Washington Local Institution - 0293, Seattle, Washington Local Institution - 0097, Spokane, Washington Northwest Cancer Specialists, P.C., Vancouver, Washington Local Institution - 0220, Madison, Wisconsin Local Institution - 0113, Zhengzhou, Henan
Local Institution - 0142, Wuhan, Hubei Local Institution - 0155, Changsha, Hunan Local Institution - 0147, Changsha, Hunan Local Institution - 0111, Nanjing, Jiangsu Local Institution - 0139, Wuxi, Jiangsu Local Institution - 0287, Shenyang, Liaoning Local Institution - 0148, Xi'an, Shaanxi Local Institution - 0110, Xi'an, Shaanxi Local Institution - 0169, Qingdao, Shandong Local Institution - 0114, Shanghai, Shanghai Municipality Local Institution - 0350, Shanghai, Shanghai Municipality Local Institution - 0164, Taiyuan, Shanxi Local Institution - 0356, Deyang, Sichuan Local Institution - 0119, Tianjin, Tianjin Municipality Local Institution - 0353, Ürümqi, Xinjiang Local Institution - 0202, Kunming, Yunnan Local Institution - 0151, Hangzhou, Zhejiang Local Institution - 0348, Linhai, Zhejiang Local Institution - 0112, Ningbo, Zhejiang Local Institution - 0149, Wenzhou, Zhejiang Local Institution - 0150, Beijing Local Institution - 0176, Taiyuan Asklepios Altona, Hamburg
Universitaetsklinikum Tuebingen, Tübingen Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher, Würzburg Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima Kumamoto University, Kumamoto The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki The Jikei University Hospital, Tokyo Japanese Red Cross Medical Center, Tokyo Local Institution - 0100, Seoul Severance Hospital, Yonsei University Health System, Seoul