Plain-English translation of NCT05526924 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a combination of treatments for head and neck cancer that has come back after prior therapy. The study combines radiation therapy with chemotherapy drugs and two experimental medications: and . Researchers want to find the safest and most effective dose of these medications when used together.
Head and neck cancer that returns after initial treatment is very difficult to treat, and standard options are limited. This medication may help boost the body's immune system to fight cancer cells while the radiation and chemotherapy work directly on tumors.
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You will receive one dose of medication by IV before starting the main treatment phase. Then you will undergo 5 weeks of combined therapy: daily chemotherapy pills, radiation twice daily, and daily medication, followed by about 8 days of rest. After completing this 15-month active treatment period, you will return to the clinic every 4 months for 2 years, then every 6 months for 2 more years, and then once yearly for the rest of your life for follow-up appointments.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States