Plain-English translation of NCT05528471 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether reducing fructose and high-fructose corn syrup in the diet can help improve liver health in teenagers with non-alcoholic fatty liver disease. The study compares two groups: one eating a low-sugar diet (about 5% of calories from sugar) and another eating a regular diet with more sugar (about 10% of calories from sugar). Researchers will measure changes in liver function, blood sugar control, and overall metabolic health over six months.
Fatty liver disease is becoming more common in obese children and teenagers, and high sugar intake—especially from high-fructose corn syrup—is thought to be a major cause. While weight loss helps, doctors don't yet have clear dietary guidelines for treating this condition, so this study aims to find out if cutting back on sugar specifically can reduce liver damage and improve health markers.
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You will be randomly assigned to follow either a low-sugar diet or a regular diet for six months. Both diets will provide the same total calories—the main difference is how much sugar you eat. During the study, you'll visit the clinic several times for blood tests and special MRI scans that measure liver fat and energy. Researchers will also monitor your blood pressure, body composition, and blood sugar control to see how the diet affects your health.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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