Plain-English translation of NCT05529940 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a new treatment schedule for people with pancreatic cancer that can be surgically removed. The study compares two approaches: one group receives (a combination chemotherapy) before surgery and again after surgery, while the other group has surgery first and then receives chemotherapy. Researchers want to see if treating cancer with chemotherapy before removing it surgically helps patients live longer.
Currently, most patients receive chemotherapy only after pancreatic cancer surgery, but many don't complete the full treatment plan. This medication given before surgery might help control cancer that has spread in ways doctors cannot yet see, increase the chances of complete tumor removal, and help more patients finish their full course of treatment.
You likely qualify if…
You likely don't qualify if…
If you are randomly selected for the chemotherapy-first group, you will receive six cycles of chemotherapy as an outpatient, then have surgery to remove the tumor, and then receive six more cycles of chemotherapy. If you are in the surgery-first group, you will have surgery first, followed by twelve cycles of chemotherapy. Both groups will have regular doctor visits, blood tests, and scans to monitor your progress. The trial will track how long you survive and how well you tolerate the treatment over several years.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
South Korea