Receive two different tissue sampling methods during endoscopy screening

Recruiting

What is this trial?

This trial is testing whether a newer brushing technique called WATS3D can find precancerous changes in the esophagus better than the traditional method of taking small tissue samples. The study involves people who have Barrett's esophagus (a condition where cells in the esophagus have changed due to acid reflux) or are being screened for it. Both sampling methods will be used during the same endoscopy visit so doctors can compare how well each one works.

Barrett's esophagus can sometimes turn into esophageal cancer, so doctors need to find any precancerous changes early. This trial is trying to figure out if the newer brushing technique catches more of these dangerous changes than the traditional biopsy method, which could help patients get better care and earlier treatment if needed.

Do you qualify?

You likely qualify if…

you have been diagnosed with non-dysplastic Barrett's esophagus and are coming for routine monitoring, or you are being screened for Barrett's esophagus
your Barrett's esophagus extends at least a certain length in your esophagus
you are between 18 and 89 years old
you are able to speak English or Spanish and understand the study information
you are expected to live at least 2 more years

You likely don't qualify if…

you have been treated with endoscopic therapy for dysplasia or esophageal cancer in the past
you have severe acid reflux damage (Grade B or higher) in your esophagus
you have enlarged veins in your esophagus (varices)
you have had previous surgery on your esophagus or stomach (except a simple reflux surgery)
you are pregnant

What participation looks like

You will have an upper endoscopy (a camera is passed down your throat to look at your esophagus). During this single procedure, doctors will use both sampling methods on you: one group will receive the traditional method first followed by the newer brushing technique, while the other group will receive them in the opposite order. All biopsies will be sent to a specialist for review, and if the results differ between the two methods, you may need a follow-up endoscopy to confirm findings.

Comparing two methods to detect precancerous changes in the esophagus

What is this trial?

Do you qualify?

What participation looks like

Trial locations(14 sites)