Plain-English translation of NCT05539040 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Atrial fibrillation is a common heart rhythm problem that can cause discomfort and increase stroke risk. The standard treatment is a procedure called catheter ablation, which works about 60–70% of the time. This study is testing whether adding ablation of nerve endings in the right atrium—in addition to the standard treatment—can help people for whom the standard approach alone hasn't been effective.
For some patients, the current standard treatment for atrial fibrillation doesn't work well enough. Researchers have discovered nerve endings in the heart that trigger the irregular rhythm, and early results suggest that treating these nerve endings in the right side of the heart may help people who need a second procedure.
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If you join this study, you will be randomly assigned to one of two groups. Both groups will receive the standard ablation procedure plus pulmonary vein isolation (the usual treatment). One group will also receive additional ablation targeting nerve endings in the right atrium. The procedure takes place at Hammersmith Hospital, and your medical information will be kept private and encrypted. You'll continue with your regular NHS care throughout the study.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United Kingdom