Plain-English translation of NCT05541276 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether —a natural hormone your body makes—can help prevent agitation and confusion that sometimes occurs when young children wake up from anesthesia. About 1 in 4 children experience this kind of behavior after surgery, and the research team wants to see if giving this medication intravenously (through an IV) about 30 minutes before the end of surgery can reduce these symptoms. The study is designed so neither the families nor the doctors will know who received the actual medication versus a placebo (salt water), to make sure the results are fair and unbiased.
When children wake up from surgery, some experience distressing symptoms like crying, thrashing, and confusion—something called emergence delirium. Researchers believe this medication might prevent or reduce these symptoms, and they want to study it carefully in a large group of children to see if it's safe and effective.
You likely qualify if…
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If your child is enrolled, about 30 minutes before the surgery ends, your child will receive a single injection through an IV—either the study medication or placebo (salt water). Neither you nor the surgical team will know which one your child receives. The injection is a one-time dose given during the surgery itself, so there are no additional visits or long-term commitments. After surgery, the doctors will monitor your child's behavior as they wake up to see how they respond.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
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