Plain-English translation of NCT05541887 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether muscadine wine polyphenols—natural compounds found in muscadine grapes—can help improve memory, thinking skills, mood, and anxiety in adults over 50. The medication has natural anti-inflammatory and antioxidant properties that researchers believe might benefit brain health. This is the first human study to examine whether this treatment can actually help with these issues.
Scientists believe that inflammation and oxidative stress in the brain may contribute to memory problems, depression, and anxiety, but current treatments don't work for everyone. Similar polyphenol-rich foods like blueberries and grape juice have shown promise in earlier studies, but no one has yet tested whether this specific medication works in humans.
You would participate in a 13-week study where you take either the muscadine wine extract or a placebo (inactive pill) for 6 weeks, then switch to the other for another 6 weeks, with a 3-week break in between to let your body clear the first treatment. Throughout the study, you would complete tests of memory and thinking, answer questions about your mood and anxiety, and likely have blood drawn to measure inflammation and other markers.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
United States
Sponsor
University of Florida
Enrollment target
~25 participants
Started
August 2023
Primary completion
December 2028
Age range
50 Years – 65 Years
Last updated on clinicaltrials.gov in August 2026.