Recruiting

Testing a new surgical rinse to prevent joint infections after hip or knee replacement

Plain-English translation of NCT05543941 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

If you're having hip or knee replacement surgery, this trial is testing whether a new surgical rinse called XPERIENCE Advanced Surgical Irrigation can better prevent infections around your new joint compared to a standard rinse (dilute Betadine) that doctors currently use. You would be randomly assigned to receive one of these two rinses during your surgery, and then followed to see if either one reduces your risk of infection.

Infections after joint replacement surgery can be serious and costly to treat. Doctors want to find the best way to rinse the surgical area during the operation to lower the chance that an infection develops.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with osteoarthritis, inflammatory arthritis, or another joint condition affecting your hip or knee
you are having your first total hip, knee, or hip resurfacing replacement surgery
you are able and willing to attend follow-up visits after surgery
you speak English or French and can sign an informed consent form

You likely don't qualify if…

you have had joint replacement surgery before on the same hip or knee
you are allergic to iodine or any ingredient in the XPERIENCE rinse
you have had an active infection in that joint within the past two years
you have a weakened immune system, uncontrolled HIV, or are taking immunosuppressive medications for cancer or autoimmune disease
you received a steroid injection in that joint within three months before your scheduled surgery

What participation looks like

You will undergo your hip or knee replacement surgery as planned. During the operation, before the surgeon closes the wound, your surgical site will be rinsed with either the new XPERIENCE irrigation solution or the standard dilute Betadine rinse (you won't know which one you received). After surgery, you will attend follow-up visits so the research team can check whether your joint heals well and monitor you for any signs of infection.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(8 sites)

Canada

University of British Columbia, Vancouver, British Columbia

London Health Sciences Center, London, Ontario

The Ottawa Hospital, Ottawa, Ontario

Humber River Health, Toronto, Ontario

St. Joseph's Health Centre, Toronto, Ontario