Plain-English translation of NCT05545306 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study measures how your body uses energy (burns calories) when you eat different amounts of food—from fasting all the way up to eating much more than you normally would. By studying these differences, researchers want to understand why some people's bodies respond differently to changes in how much they eat, which could help explain differences in weight gain and metabolism between individuals.
Scientists know that eating more food causes your body to burn slightly more calories, but they don't fully understand why this response varies so much from person to person. This research could help explain why some people find it easier or harder to maintain their weight, and could lead to better approaches to managing weight and metabolism.
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You will spend multiple nights in a special sealed room called a respiratory chamber that measures exactly how many calories your body burns. During each stay, you will eat one liquid meal containing a specific number of calories—ranging from fasting (no food) to eating much larger amounts than normal. The study uses randomized testing order, meaning the sequence of different calorie levels will be different for different participants, and the researchers will measure your metabolic response to each level.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States