Combining immunotherapy and radiation before surgery for rare melanomas

This trial is testing a new approach to treating two rare types of melanoma—one that starts in the sinuses and one that starts in the rectal area. The study combines immunotherapy (which helps your body's immune system fight cancer) with radiation therapy, given before surgery to remove the tumor. Researchers want to see whether this combination approach helps shrink tumors and improves how well surgery works.

These types of melanoma are extremely rare and difficult to treat, and surgery alone doesn't always work well enough. This trial is testing whether giving the medication and radiation first can make tumors smaller and easier to remove, and potentially improve long-term outcomes.