Testing a new treatment for inherited early-onset Alzheimer's disease

This trial is testing an investigational medication called Remternetug to see if it can help prevent or slow memory and thinking problems in people who carry a specific genetic mutation linked to early-onset Alzheimer's disease. You would be considered for this study if you either have the genetic mutation or are at risk of inheriting it from a parent, but you don't yet have any memory or thinking problems. The medication is being compared to placebo (a dummy pill with no active drug) to understand whether it really works.

Researchers have identified families where a genetic mutation nearly always causes Alzheimer's disease at a predictable age. This trial exists because treating people before symptoms appear — while their brains are still healthy — may offer the best chance to prevent or delay the disease. By studying people who we know will develop this condition, scientists can test whether the medication actually works to protect the brain.