Plain-English translation of NCT05553353 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation treatment — to see if it can help reduce depression in people with spinal cord injuries. The main challenge is figuring out the right dose for each person, especially for those with weakness in their arms or hands. This study uses a new computer-based method to personalize the treatment dose for each participant.
Depression is very common after spinal cord injury and significantly impacts quality of life, but current treatment options are limited for this population. The standard way of dosing this treatment doesn't work well for people with spinal cord injuries because it relies on being able to move certain hand muscles — something many people with these injuries cannot do.
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If you join this study, you will come to the clinic 5 days a week for 6 weeks to receive brain stimulation sessions. You will be randomly assigned to receive either the active treatment or a sham (placebo) treatment that looks the same but doesn't deliver the actual stimulation. Throughout the study, the research team will monitor your mood and depression symptoms to see if the treatment helps.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
United States