Testing a new heart failure medication against an existing treatment

Plain-English translation of NCT05553886 on ClinicalTrials.gov ↗ · Source last updated November 2022 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing a new medication called S086 tablets to see if it can help people with chronic heart failure where the heart doesn't pump strongly enough. Researchers will compare S086 to an existing heart failure drug called sacubitril valsartan to learn which treatment works better and is safer for patients.

Heart failure with a weak heartbeat is a serious condition, and doctors are always looking for better treatment options. This study will help determine whether this medication offers improved benefits or safety compared to the current standard treatment.

Do you qualify?

You likely qualify if…

you have been diagnosed with chronic heart failure with a weakened heartbeat (ejection fraction of 40% or less)
you have elevated levels of a heart-related protein called BNP in your blood
you have been taking stable doses of your current heart failure medications for at least 4 weeks before joining
you are willing to volunteer and sign an informed consent form

You likely don't qualify if…

you have taken high doses of sacubitril valsartan (150mg twice daily or more) for more than 3 months before the study
you have a known or suspected allergy to this medication or related heart drugs
you have had a history of angioedema (severe allergic swelling) in the past
you experienced a heart attack within the 6 weeks before the study begins
you had severe side effects or couldn't tolerate similar blood pressure or heart medications in the past

What participation looks like

You would take the study medication by mouth at doses that are slowly increased over time, with your doctor adjusting the dose based on how you respond. You'll visit the clinic multiple times so researchers can check your heart function, measure your blood pressure and heart rate, and ask how you're feeling. The study compares your experience on the new medication to others taking the standard heart failure drug to see which works best.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

China

Shenzhen People' S Hospital, Shenzhen, Guangdong