Plain-English translation of NCT05561738 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether Nicotinamide Riboside Chloride, a natural supplement, can help children with ulcerative colitis feel better and have fewer symptoms. The researchers believe this medication may help repair damage to the intestinal lining by restoring energy to gut cells. Half of the participants will receive the active supplement, and half will receive a placebo (dummy pill) that looks identical, while both groups continue their regular ulcerative colitis treatment.
Ulcerative colitis damages the intestinal lining, partly because gut cells don't have enough energy to repair themselves. This trial aims to see if this treatment can restore that cellular energy and reduce inflammation, offering a new way to support standard ulcerative colitis care.
You likely qualify if…
You likely don't qualify if…
You will take a daily capsule (either the supplement or placebo) matched to your body weight, in addition to your regular ulcerative colitis medications. You will have a colonoscopy (a procedure to look inside your colon) to confirm your diagnosis and assess your symptoms before and during the study. The study team will monitor how you respond over time and track any changes in your symptoms and gut health.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Sponsor
University of Pittsburgh
Collaborators
Crohn's and Colitis Foundation
Enrollment target
~40 participants
Started
February 2024
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Min Shi
University of Pittsburgh
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.