Plain-English translation of NCT05562167 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Heart Failure research guide โPhase 2 โ Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing potassium nitrate, a natural mineral compound, to see if it can help people with heart failure exercise better and feel less tired. Half of the participants will receive the actual medication, and half will receive a placebo (a pill that looks identical but has no active ingredient). The goal is to understand whether this simple, inexpensive supplement can improve how well your heart works during physical activity.
People with heart failure often struggle with exercise and feel exhausted, even when doing light activities. This medication may help your body produce more nitric oxide, a natural chemical that relaxes blood vessels and improves blood flow โ which could make exercise easier and less tiring.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
You'll attend a screening visit to confirm you're eligible, then return for a baseline visit (both at Washington University School of Medicine). Over 6 weeks, you'll take one capsule by mouth every day โ either the active medication or placebo. You'll return for follow-up visits where researchers will measure your blood pressure, blood oxygen, exercise capacity, and quality of life. The study involves some blood draws, heart imaging, and exercise tests to see how well the medication works.
AI-generated summary from trial data ยท Jun 25, 2026 ยท Not medical advice
United States