Plain-English translation of NCT05565443 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new way to treat Parkinson's disease by using focused ultrasound — a kind of sound wave technology — to open a protective barrier around the brain and deliver recombinant glucocerebrosidase (GCase), an enzyme medication, directly to a specific brain area called the putamen. The study will enroll 14 people with Parkinson's disease and follow them for one year to see if this approach is safe and effective.
Standard Parkinson's medications work throughout the body but have difficulty crossing into the brain where they're needed most. This trial is exploring whether ultrasound technology can create a temporary opening in the brain's protective barrier to allow this medication to reach the exact areas affected by Parkinson's, potentially offering a more direct and effective treatment approach.
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You would receive three treatment sessions, spaced two weeks apart, in which focused ultrasound is used to temporarily open the blood-brain barrier in your putamen while the GCase medication is infused intravenously. Each participant will receive either a lower or higher dose depending on safety results from earlier participants. After completing the three treatments, you will return for follow-up visits over the next 12 months so doctors can monitor how you respond and check for any side effects.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
Canada
Sponsor
InSightec
Enrollment target
~14 participants
Started
November 2022
Primary completion
December 2027
Age range
35 Years – 80 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Alyssa Voelker-Christy
InSightec
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.