Plain-English translation of NCT05567198 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Women with severe lupus are sometimes treated with cyclophosphamide, a powerful drug that can damage the ovaries and affect fertility. This study is testing whether adding leuprolide acetate—a hormone injection—alongside cyclophosphamide can protect the ovaries from damage. Researchers will survey and review medical records of women who received cyclophosphamide with and without this medication to see if the medication helps preserve ovarian function.
Cyclophosphamide is a lifesaving treatment for serious lupus, but it can harm the ovaries and cause early menopause or infertility. Doctors believe that this medication might protect the ovaries during treatment, but there isn't enough research yet to prove whether it actually works.
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You will be asked to complete a survey about your health history and reproductive health. Researchers will also review your medical records to learn about your lupus treatment, the doses of cyclophosphamide you received, and whether your ovarian function has been affected. There are no study visits or new treatments—you are simply sharing information to help doctors understand whether the hormone injection works.
AI-generated summary from trial data · Oct 5, 2026 · Not medical advice
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