Plain-English translation of NCT05567198 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing whether a hormone medication called leuprolide acetate can protect a woman's ovaries when she receives cyclophosphamide—a powerful drug used to treat serious lupus. Cyclophosphamide can damage ovaries and affect fertility, but researchers think giving the hormone medication at the same time might prevent that damage. The study will compare women who received both treatments to those who received only cyclophosphamide, to see if the medication offers protection.
Women with severe lupus often need cyclophosphamide to save their lives, but this drug can harm the ovaries and make it harder to have children later. Doctors have wondered whether this medication could protect ovaries during treatment, but there hasn't been enough evidence to know for sure.
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This is a survey and medical records study, not a treatment trial. Researchers will ask you questions about your health history, lupus disease, and whether you've had problems with your periods or fertility since receiving cyclophosphamide. They will also review your medical records to gather information about your ovarian health. You won't need to take any new medication or attend many clinic visits—most participation happens through questionnaires and chart review.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States