Plain-English translation of NCT05571644 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether cadonilimab, an immunotherapy drug, works better when combined with chemotherapy before surgery for advanced colorectal cancer. Researchers want to know if adding this medication to standard chemotherapy can help shrink tumors more effectively and improve outcomes for patients. You would receive 6 cycles of treatment before having surgery to remove the cancer.
Standard chemotherapy before surgery helps many patients with advanced colorectal cancer, but doctors want to see if adding this immunotherapy medication can make the treatment even more effective. The goal is to help more patients achieve better tumor shrinkage and potentially improve their long-term survival.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive either chemotherapy alone or chemotherapy combined with the immunotherapy medication cadonilimab. You will receive 6 cycles of treatment, given every two weeks, before you have surgery to remove the cancer. The study team will check on you after 3 cycles and again after 6 cycles to see how well the treatment is working, and then you will have surgery followed by standard care after your operation.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
China