Plain-English translation of NCT05576103 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is tracking what happens to your brain after you receive radiation therapy for a primary brain tumor. Researchers want to understand how radiation affects both your thinking and memory (what doctors call neurocognitive function) and the actual structure of your brain tissue, so they can eventually design radiation treatments that are safer and cause less harm to healthy brain areas.
Radiation therapy is an important treatment for brain tumors, but we know it can affect thinking, memory, and brain tissue in up to 90% of patients who survive more than six months. This trial exists to map exactly which parts of the brain are most vulnerable so future doctors can plan radiation more carefully and reduce these side effects.
You likely qualify if…
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You will visit the clinic four times over one year: before your radiation treatment starts, and then again at 3 months, 6 months, and 12 months after treatment ends. At each visit, you'll have an MRI brain scan (standard care you'd get anyway) and complete a battery of thinking and memory tests—these take about an hour and include tasks like word recall, attention, and problem-solving. The research team will also collect information about your tumor, medications, and general health.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
United States
Sponsor
Jona Hattangadi-Gluth
Enrollment target
~300 participants
Started
January 2015
Primary completion
December 2030
Age range
18 Years – 99 Years
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sheila Medina
Jona Hattangadi-Gluth
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.