Plain-English translation of NCT05580211 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a safe, non-invasive brainstem neuromodulation device designed to help people with schizophrenia become more aware of their illness. Many people with schizophrenia struggle to recognize that they have the condition, which makes it hard to stay on medications and get better. Researchers will use brain imaging to see how the device affects both the brain and illness awareness.
Lack of illness awareness is one of the hardest-to-treat parts of schizophrenia and a major reason why people stop taking their medications. This trial exists to explore whether non-invasive brain stimulation could help change this and improve how people respond to treatment.
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You will receive non-invasive brainstem stimulation using an investigational device, either in one of two randomized stimulation patterns or in an open-label group. Throughout the study, your brain activity will be measured using imaging scans to track changes in illness awareness. You'll need to be on stable medications and available for study visits to receive the stimulation and complete the assessments.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Canada
Sponsor
Scion NeuroStim
Collaborators
Centre for Addiction and Mental Health
Enrollment target
~34 participants
Started
October 2023
Primary completion
October 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Phillip Gerretson, MD
Scion NeuroStim
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.