Plain-English translation of NCT05582837 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This 8-week study is testing whether a combination of nortriptyline and topiramate—two medications commonly used for migraines—can help reduce symptoms of Meniere's disease, an inner ear condition that causes dizziness, hearing loss, and ear ringing. One group will take the medication while another will take a different treatment approach, and researchers will track how well each works by checking in with you weekly.
Meniere's disease can be difficult to treat, and doctors are always looking for new ways to help patients feel better. This medication combination has shown promise in helping with similar conditions, so researchers want to test whether it can also help people with Meniere's disease.
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You'll be randomly assigned to take either the new medication combination or a standard treatment for 8 weeks. You'll start with a low dose that may increase weekly depending on how you're feeling. You'll visit the clinic before the study starts, then weekly for check-ins where researchers will ask how you're doing and adjust your medication if needed. The whole study takes about 2 months.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Sponsor
University of California, Irvine
Enrollment target
~40 participants
Started
August 2022
Primary completion
December 2027
Age range
25 Years – 85 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Hamid R Djalilian
University of California, Irvine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.