Plain-English translation of NCT05583721 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Sickle Cell Disease research guide โPhase 2 โ Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Researchers want to understand how sickle cell disease affects the heart's ability to pump blood efficiently. This study uses two types of heart imaging โ an ultrasound and a special PET scan โ to see if there's a connection between reduced blood flow to the heart and problems with how the heart relaxes between beats. By studying this relationship, doctors hope to catch and prevent heart problems earlier in people with sickle cell disease.
People with sickle cell disease are at higher risk for heart problems, but doctors don't fully understand how the disease damages the heart over time. This research could help identify warning signs before serious complications develop.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
You will have two study visits. At the first visit, you'll get blood tests, an EKG (a simple heart electrical test), and an ultrasound of your heart. At the second visit, you'll have a PET stress test, which involves receiving an injection and exercising (or being given a medication to simulate exercise) while the scanner takes pictures of your heart's blood flow. You'll also have follow-up phone calls the day after and one week after your final imaging test.
AI-generated summary from trial data ยท Jun 6, 2026 ยท Not medical advice
United States