Plain-English translation of NCT05584488 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Columbia University are studying people with genetic disorders that affect how the immune system and allergic responses work. They want to understand why some people develop severe allergies, immune deficiencies, or conditions where the immune system attacks itself. By collecting blood samples and learning about participants' medical histories, the team hopes to discover new genes and biological pathways involved in these diseases.
Many allergic and immune disorders run in families, but doctors don't fully understand the genetic causes. By studying patients and their relatives, researchers can identify new disease-causing genes and develop better ways to diagnose, treat, and potentially prevent these conditions.
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You would donate a blood sample for genetic and immune system testing, and share information about your medical history and symptoms. Family members may also be asked to participate. Your blood will be stored and studied over time to help researchers understand the genetic basis of allergic and immune disorders—this is a long-term registry study, not a short-term treatment trial.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
Columbia University
Enrollment target
~10,000 participants
Started
July 2010
Primary completion
January 2027
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Joshua D. Milner, MD
Columbia University
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