Plain-English translation of NCT05589753 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This research focuses on a serious problem: when Veterans take prescription opioid pain medications, they sometimes experience dangerous pauses in breathing during sleep. The study is testing two potential treatments—sustained oxygen therapy overnight and , an oral medication—to see if either can help stabilize breathing and reduce these harmful interruptions.
Opioid pain medications can dangerously affect how the body controls breathing during sleep, but doctors don't fully understand why this happens or have good treatment options. This trial aims to develop personalized therapies that could reduce breathing problems and improve survival for Veterans taking these medications.
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You will complete overnight sleep studies where researchers monitor your breathing while you sleep. Depending on which treatment group you join, you may spend a night breathing extra oxygen, or you may take (a pill) for 6 days while completing several daytime and nighttime breathing tests and sleep studies. The studies measure how your body controls breathing and how it responds to carbon dioxide levels.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States