Plain-English translation of NCT05589753 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether two approaches—breathing extra oxygen overnight or taking a medication called —can help reduce dangerous breathing interruptions during sleep in Veterans who take prescription opioid pain medications. Right now, there are few good treatments for this serious problem, and researchers don't fully understand why opioids cause breathing problems at night. This study aims to find new, personalized ways to keep Veterans safer.
Veterans taking prescription opioids for pain often experience serious breathing problems during sleep, which can lead to overdose and death. Current treatments are limited and don't work well for everyone, so researchers need to test new approaches to protect Veterans and improve their health.
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You would participate in overnight sleep studies where researchers measure your breathing and oxygen levels while you sleep, and possibly daytime breathing tests while awake. Depending on which group you're assigned to, you would either breathe extra oxygen one night, take the medication for 6 days while undergoing multiple tests, or both. The full study involves several visits over a period of weeks to a VA research facility.
AI-generated summary from trial data · Jul 9, 2026 · Not medical advice
United States