Plain-English translation of NCT05590689 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Glioblastoma research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new way to treat glioblastoma (a serious brain cancer) when it comes back after initial treatment. The study combines a medication called 5-ALA with radiation therapy to see if this combination works better than radiation alone. The medication has already been safely used during surgery to help doctors see cancer cells, and now researchers want to see if using it multiple times during radiation therapy can improve outcomes.
When glioblastoma comes back, treatment options are limited and outcomes are not always good. Researchers believe that using this medication during radiation therapy might make the radiation more effective at killing cancer cells, potentially helping patients live longer and better.
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If you join this trial, you will receive surgery to remove the recurrent tumor (if planned), followed by radiation therapy combined with doses of the study medication given during your treatment course. The exact schedule and number of medication doses will depend on which group you are placed in, as researchers are testing different amounts and frequencies. You will have regular imaging scans and blood tests to check how well the treatment is working and to monitor for any side effects.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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