Plain-English translation of NCT05592886 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Neoplasms research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new oral supplement called SMT04, which combines beneficial bacteria (probiotics) with special dietary fibers (prebiotics), in people who have recently had advanced polyps removed from their colon. Researchers believe that certain harmful bacteria in the gut may increase the risk of polyps returning, and that SMT04 might help reduce those harmful bacteria and prevent polyp recurrence. The study will compare people who take SMT04 daily with people who take a placebo (inactive pill) to see if the medication can actually prevent polyps from coming back.
Recent research shows that an imbalance in gut bacteria is linked to polyp growth and colorectal cancer risk. While probiotics have shown promise in laboratory studies, it's still unclear whether this particular combination treatment can have a lasting protective effect in real patients.
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You will take a daily dose of either the SMT04 supplement or a placebo for about 12 weeks, neither you nor the researchers will know which one you're receiving. You'll visit the study clinic at several timepoints to provide stool samples and have your bacterial markers checked. After the treatment period, you'll return for surveillance colonoscopies (as you would normally after polyp removal) to see if polyps have returned, which will be compared between the treatment and placebo groups.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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