Plain-English translation of NCT05593549 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Type 2 Diabetes research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is exploring whether , a natural compound, can help improve blood vessel function in people with type 2 diabetes. Your blood vessels rely on special molecules to relax and expand properly, and diabetes can interfere with this process. Researchers want to understand whether this medication might help restore normal blood vessel function by activating a cellular repair system called autophagy.
People with type 2 diabetes often develop problems with their blood vessels that can lead to heart disease and stroke. Scientists have discovered that damaged cells inside blood vessels aren't being cleaned up properly in diabetes, which disrupts how blood vessels respond to blood flow. This study aims to test whether activating the body's natural cleanup system could restore healthy blood vessel function and potentially prevent cardiovascular complications.
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You will take either or a placebo (an inactive substance) mixed with water once daily. The study involves blood vessel function tests and blood draws to measure how your blood vessels respond and to track cellular markers of the cleanup system researchers are studying. You'll visit the research center multiple times over the study period for these assessments, allowing doctors to compare how the medication affects blood vessel function compared to placebo.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States