Plain-English translation of NCT05599347 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a 5-day course of azithromycin—a common antibiotic—taken before starting a TNF-blocking medication (like infliximab or adalimumab) can help your body respond better to the treatment. Researchers have noticed a connection between gut bacteria and how well these medications work, and they believe this antibiotic might improve outcomes by changing your gut bacteria in a helpful way.
Many people with Crohn's disease don't respond well to TNF-blocking medications because their immune system develops antibodies against the drug. Current ways to prevent this involve taking other immunosuppressive drugs, which can have serious side effects. This study is exploring whether a simple antibiotic course before treatment could be a safer, simpler way to help the medication work better.
You likely qualify if…
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You would be randomly assigned to either take azithromycin or a placebo (dummy pill) once daily for 5 consecutive days, then start your scheduled TNF-blocking medication. Researchers will monitor you over the course of a year to see how well the medication works and whether your body develops antibodies against it. You'll need to attend study visits and have blood tests to measure your response.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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