Cooling wraps to prevent nerve damage from cancer drugs

Plain-English translation of NCT05606068 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a novel device called a limb cryocompression system—essentially cooling wraps that are wrapped around your arms and legs—to see if it can prevent chemotherapy-induced peripheral neuropathy, a common side effect where patients experience numbness, tingling, or pain in their extremities. The study will enroll 200 cancer patients receiving weekly paclitaxel chemotherapy (with or without other chemotherapy drugs) and apply the cooling wraps during their treatment cycles to determine whether this treatment is safe and effective when used repeatedly.

Many cancer patients experience nerve damage as a side effect of chemotherapy, which can cause persistent pain and numbness in the hands and feet. This trial is exploring whether cooling the limbs during chemotherapy can prevent or reduce this nerve damage, offering patients a way to protect themselves from this difficult long-term side effect.

Do you qualify?

You likely qualify if…

you are between 21 and 80 years old
you have been diagnosed with cancer and are scheduled to receive weekly paclitaxel chemotherapy
you may also be receiving other chemotherapy drugs alongside your primary treatment
you do not already have significant nerve damage from chemotherapy at the start of the study

You likely don't qualify if…

you have open skin wounds or ulcers on your arms or legs
you have a history of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes
you are pregnant
you already have moderate to severe nerve damage symptoms before the study begins

What participation looks like

You would receive cooling wraps applied to your limbs (from your fingers or toes up to your elbows or knees) during each cycle of your weekly chemotherapy treatment. The wraps use a cooling device set to a specific temperature and pressure that was determined to be safe and effective in earlier studies. You would undergo this cooling treatment repeatedly across multiple chemotherapy cycles so researchers can monitor whether it is tolerated well and whether it helps prevent the nerve damage that chemotherapy can cause.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Trial locations(2 sites)

Singapore

National University Hospital, Singapore

Curie Oncology, Mount Elizabeth Novena Specialist Centre, Singapore