Plain-English translation of NCT05607407 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Glioblastoma research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a medication called can help treat glioblastoma, a serious brain tumor. The researchers believe that lowering thyroid hormone levels may boost a natural protective substance in the brain that slows tumor growth. This medication would be taken alongside your standard cancer treatment.
Laboratory studies show that a natural chemical in the body may help fight glioblastoma, but patients don't make enough of it. This trial is testing whether this medication can safely increase that protective chemical and help extend survival when used with standard therapy.
You would start taking the medication by mouth at least 5 days before your planned surgery, or until your thyroid hormone levels drop. After surgery, you would wait at least 10 days before restarting the medication for 4 weeks, during which your doctors would check your blood and do MRI scans to see how you're responding. You would have multiple blood draws to measure how the medication is working in your body, and your doctors may add standard chemotherapy at their discretion.
AI-generated summary from trial data · Aug 17, 2026 · Not medical advice
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