Plain-English translation of NCT05607654 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a faster, more intensive version of repetitive transcranial magnetic stimulation (rTMS) — a procedure that uses magnetic pulses to stimulate specific areas of the brain — for people whose depression hasn't responded to antidepressant medications. Researchers want to understand how this accelerated treatment works by measuring changes in brain activity and certain proteins in your blood before treatment, 5 days after, and one month later.
Many people with depression don't improve even after trying multiple medications, leaving them with few options. This trial exists to learn whether a faster, more intensive version of brain stimulation might help these patients, and to understand the biological mechanisms that make it work.
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If you join this trial, you will be randomly assigned to receive either the active brain stimulation treatment or a sham (fake) treatment. The active treatment involves 10 sessions per day for 5 consecutive days, with each session lasting about 10 minutes. You will have brain imaging scans and blood tests at the start, after 5 days of treatment, and again one month later to measure changes in your brain activity and specific biological markers.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
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