Plain-English translation of NCT05608213 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether combining (a daily pill) with a special procedure called iodine-125 seed brachytherapy works better than alone for people with advanced liver cancer. In this procedure, tiny radioactive seeds are placed directly into the tumor under imaging guidance to help destroy the cancer. The trial will compare how well patients do with both treatments versus the pill alone.
Some patients with advanced liver cancer stop responding to a standard treatment called TACE (a procedure that delivers chemotherapy directly to the tumor). Researchers want to know if adding this seed implant procedure to the medication can help patients live longer and control their cancer better.
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If you join this trial, you will take a daily pill () for as long as it helps your cancer. If you are randomly assigned to the combination group, you will also have a procedure within 7 days where radioactive seeds are placed into your tumor using imaging guidance — this is done once, but may be repeated later if needed based on your scans and blood tests. You will have regular follow-up visits with blood work and imaging to monitor how you are doing and check for side effects.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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