Plain-English translation of NCT05608694 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether MRI scans with contrast dye can find prostate cancer earlier and more effectively in men who are at higher genetic risk for developing the disease. Researchers will compare MRI results between men with known genetic mutations linked to prostate cancer, men with high genetic risk scores, men with a family history of prostate cancer, and men with average risk. The goal is to understand whether genetic testing can help doctors decide which men would benefit most from MRI screening.
Prostate cancer can be aggressive and hard to detect early, especially in men with genetic factors that increase their risk. This study aims to find out whether personalized screening based on genetics and advanced imaging can catch dangerous cancers sooner, when they may be easier to treat.
You likely qualify if…
You likely don't qualify if…
You will come to the hospital or imaging center for an MRI scan of your prostate. During the scan, you will receive an intravenous injection of contrast dye (gadolinium) to help create clearer images. The scan itself typically takes 30–60 minutes while you lie still inside the MRI machine. Researchers will compare your scan results to your genetic information to evaluate whether genetic risk factors help predict which men benefit most from this type of screening.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
United States
Sponsor
University of Chicago
Enrollment target
~250 participants
Started
March 2022
Primary completion
March 2037
Age range
18 Years and older
Sex
Male only
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Scott Eggener, MD
University of Chicago
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