Plain-English translation of NCT05612347 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Colon polyps are growths that can sometimes develop into cancer, so doctors recommend follow-up monitoring. This trial is testing whether a simple at-home stool test called FIT (fecal immunochemical test) works just as well as colonoscopy for keeping an eye on older adults who have had small polyps in the past. The goal is to give older adults a less invasive option for regular monitoring that doesn't require sedation or the small risks that come with colonoscopy.
Many older adults are nervous about repeated colonoscopies because of the sedation, recovery time, and small risks of bleeding or perforation—especially if they only had small, low-risk polyps. This treatment is already used for screening in other countries and has worked well, but doctors in the US want to know if it's a safe and effective alternative for older adults who need ongoing polyp monitoring.
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If you join this study, you will be randomly assigned to either the annual home stool test group or a standard colonoscopy group. If you're in the stool test group, you'll receive a kit to use at home once a year and mail it back to the lab—no sedation, no colonoscopy procedure. If you're in the colonoscopy group, you'll have one standard surveillance colonoscopy. The study team will follow your results and check in to see how you're doing and whether you had any side effects.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
United States