Plain-English translation of NCT05617495 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new approach called mindfulness-based real-time brain feedback (mbNF) for teenagers with depression. You would learn mindfulness meditation techniques while watching a live display of your own brain activity, and practice controlling that activity to reduce repetitive negative thoughts. The goal is to help your brain work in a healthier way and reduce depression symptoms.
Current depression treatments work for only about half of teenagers, and many struggle with rumination — getting stuck in cycles of repetitive, negative thinking that makes depression worse. This trial aims to create a more effective treatment by combining mindfulness with personalized feedback about your brain, which may help you learn and practice the skills more successfully.
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You would attend sessions where you first learn mindfulness meditation skills, then practice them while lying in an MRI brain scanner that shows you real-time images of your brain activity. You would practice controlling that brain activity using the mindfulness techniques you learned. Different participants will do either a 15-minute or 30-minute session of this brain feedback training, and the whole study takes about 45 minutes to complete.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States