Plain-English translation of NCT05620290 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Melanoma research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new way to treat melanoma and other skin cancers by combining MRI-guided focused ultrasound with standard radiation therapy. Before you receive radiation, doctors will use ultrasound waves to activate tiny bubbles at the tumor site, which is designed to help the radiation work more effectively. The research team wants to see if this combined approach is safe and whether it helps shrink tumors better than radiation alone.
Melanoma and skin cancers can be difficult to treat, especially when they have spread to other parts of the body. Researchers believe that using ultrasound to prepare the tumor before radiation therapy might make the radiation more powerful, offering patients a better chance at treatment success.
You likely qualify if…
You likely don't qualify if…
If you qualify and join this trial, you would receive a course of radiation therapy as planned, but before each radiation session, you'll have an MRI-guided ultrasound treatment to activate microbubbles at your tumor site. The research team will monitor your safety throughout the process and use MRI scans to see how your tumor responds to the combined treatment. You'll need to be able to stay still during the ultrasound procedure and report any sensations you experience.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
Canada
Phase
Safety & dosing
Sponsor
Sunnybrook Health Sciences Centre
Collaborators
Terry Fox Research Institute
Enrollment target
~20 participants
Started
June 2022
Primary completion
July 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Dr. Gregory Czarnota, MD, Ph.D.
Sunnybrook Health Sciences Centre
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.