Recruiting

Comparing two bowel reconstruction surgeries after colon removal for ulcerative colitis

Plain-English translation of NCT05628701 on ClinicalTrials.gov ↗ · Source last updated November 2022 · Translation generated June 2026 · How we translate trials

Read our Ulcerative Colitis research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

When ulcerative colitis becomes severe, doctors may recommend removing the entire colon. This study compares two main surgical options for rebuilding your bowel afterward: one that connects your small intestine directly to your rectum, and another that creates a pouch from your small intestine. Researchers want to learn which option gives patients the best quality of life, function, and satisfaction over time.

Both reconstructive surgeries work, but no large study has directly compared them to help patients and doctors understand the real benefits and risks of each option. This trial aims to gather that information so future patients can make the best choice for their situation.

Do you qualify?

You likely qualify if…

you are between 18 and 60 years old
you have been diagnosed with ulcerative colitis and are scheduled for or have had colon removal surgery
your rectum (the lower part of your bowel) is healthy enough and can be controlled with topical medication alone
you are eligible for both surgical reconstruction options based on your medical condition

You likely don't qualify if…

you have significant remaining inflammation in your rectum that cannot be controlled with topical medication
you have poor sphincter function (weak muscle control) or perianal disease (infection or damage around the anus)
you have had colorectal cancer or severe abnormal cell changes in the past
you have a diagnosis of primary sclerosing cholangitis (a separate liver condition) or uncertainty about your ulcerative colitis diagnosis
it has been more than 2 years since your colon removal surgery

What participation looks like

After receiving detailed information about both surgical options, you will choose which reconstruction surgery you prefer. Researchers will then follow you over time, tracking your bowel function, quality of life, complications, and satisfaction through clinic visits and questionnaires. You'll be compared with other patients who chose the same option and with patients who chose differently, so doctors can learn which approach works best for people like you.

AI-generated summary from trial data · Jun 20, 2026 · Not medical advice

Comparing two bowel reconstruction surgeries after colon removal for ulcerative colitis

What is this trial?

Do you qualify?

What participation looks like

Trial locations(4 sites)